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dc.rights.licenseCopyright © 2022, The Author(s)es
dc.contributor.authorPérez Fernández, Cristinaes
dc.contributor.authorVega, Jorgees
dc.contributor.authorRayo Pizarroso, P.es
dc.contributor.authorMateo Martí, Evaes
dc.contributor.authorRuiz Bermejo, Martaes
dc.contributor.otherCentro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC, MDM-2017-0737es
dc.date.accessioned2024-01-25T12:03:56Z-
dc.date.available2024-01-25T12:03:56Z-
dc.date.issued2022-09-07-
dc.identifier.citationScientific Reports 12: 15140 (2022)es
dc.identifier.otherhttps://www.nature.com/articles/s41598-022-19474-0es
dc.identifier.urihttp://hdl.handle.net/20.500.12666/918-
dc.description.abstractHerein, the potential of alkaline hydrothermal environments for the synthesis of possible ancestral pre-RNA nucleobases using cyanide as a primary source of carbon and nitrogen is described. Water cyanide polymerizations were assisted by microwave radiation to obtain high temperature and a relatively high pressure (MWR, 180 °C, 15 bar) and were also carried out using a conventional thermal system (CTS, 80 °C, 1 bar) to simulate subaerial and aerial hydrothermal conditions, respectively, on the early Earth. For these syntheses, the initial concentration of cyanide and the diffusion effects were studied. In addition, it is well known that hydrolysis conditions are directly related to the amount and diversity of organic molecules released from cyanide polymers. Thus, as a first step, we studied the effect of several hydrolysis procedures, generally used in prebiotic chemistry, on some of the potential pre-RNA nucleobases of interest, together with some of their isomers and/or deamination products, also presumably formed in these complex reactions. The results show that the alkaline hydrothermal scenarios with a relatively constant pH are good geological scenarios for the generation of noncanonical nucleobases using cyanide as a prebiotic precursor.es
dc.description.sponsorshipThe authors used the research facilities of the Centro de Astrobiología (CAB) and were supported by the Instituto Nacional de Técnica Aeroespacial “Esteban Terradas” (INTA); by the projects PID2019-104205GB-C21 and PID2019-107442RB-C32 from the Spanish Ministerio de Ciencia, Innovación y Universidades; and by the Spanish State Research Agency, project MDM-2017-0737 Centro de Astrobiología (CSIC-INTA), Unidad de Excelencia María de Maeztu. C.P.F. Ph-D MINECO financial support reference PRE2018-085781.es
dc.language.isoenges
dc.publisherSpringer Naturees
dc.relationinfo:eu-repo/grantAgreement/MINECO//PRE2018-085781es
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-107442RB-C32/ES/OPERACION TECNICA Y EXPLOTACION CIENTIFICA DE DATOS EN RLS DE EXOMARS, Y CONTRIBUCION AL RAX DE MMX/es
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104205GB-C21/ES/CICLO DE AEROSOLES EN MARTE Y LA TIERRA, ESTUDIO COMPARATIVO. IMPLICACIONES PARA LA VIDA Y PROTECCION PLANETARIA-ATMOSFERAS (CAMELIA-ATM)/es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationales
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/es
dc.subjectAnalytical chemistryes
dc.subjectChemical biologyes
dc.subjectOrganic chemistryes
dc.subjectChemical origin of lifees
dc.subjectPolymer chemistryes
dc.titlePrebiotic synthesis of noncanonical nucleobases under plausible alkaline hydrothermal conditionses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1038/s41598-022-19474-0-
dc.identifier.e-issn2045-2322-
dc.contributor.funderInstituto Nacional de Técnica Aeroespacial (INTA)es
dc.contributor.funderMinisterio de Economía y Competitividad (MINECO)es
dc.contributor.funderAgencia Estatal de Investigación (AEI)es
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (MICIN)es
dc.description.peerreviewedPeerreviewes
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es
dc.identifier.funderhttp://dx.doi.org/10.13039/501100010687es
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011033es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es
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