Proyecto de Investigación:
NUEVAS PLATAFORMAS BIOSENSORAS BASADAS EN MATERIALES DE BAJA DIMENSIONALIDAD. APLICACION A LA DETECCION DE BIOMARCADORES DE CANCER DE MAMA

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CTQ2017-84309-C2-1-R

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Bioelectrocatalytic platforms based on chemically modified nanodiamonds by diazonium salt chemistry
(Elsevier BV, 2020-08-05) Revenga Parra, M.; Villa Manso, A. M.; Briones, C.; Mateo Marti, Eva; Martínez Periñán, E.; Lorenzo, Encarnación; Pariente, F.; Agencia Estatal de Investigación (AEI); Comunidad de Madrid; 0000-0002-0699-7185; 0000-0003-4709-4676; 0000-0003-4709-4676; Unidad de Excelencia Científica María de Maeztu Centro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC, MDM-2017-0737
Detonation nanodiamonds immobilized onto screen-printed gold electrodes have been modified with a phenothiazine (Azure A) by electrografting of the corresponding in situ generated diazonium salt in acidic medium in the presence of nitrite. The resulting disposable electrochemical platform has been extensively characterized, confirming that is very stable and highly reactive. It shows an excellent electrocatalytic activity towards the oxidation of substances of interest and can be employed to prepare bioelectrocatalytic platforms. Hence, as proof of concept, nicotinamide adenine dinucleotide (NAD+)-dependent alcohol dehydrogenase has been directly immobilized on the Azure A electroactive film to develop an ethanol biosensor based on the measurement of the enzymatically generated β-nicotinamide adenine dinucleotide (NADH). Considering the excellent results obtained, it can be concluded that the modification of electrodes with detonation nanodiamonds can be a good strategy to generate sensing and biosensing electrochemical devices.

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